DDX

Neuromuscular weakness

• Upper motor neurons = leukodystrophe, vasculitis, brain mass, B12 deficiency anterior horn cells, spinal muscle atrophy, ALS, paraneoplastic syndrome

• Peripheral nerves = Guillain-barre, diabetic neuropathy, amyloid neuropathy (myeloma), lead poisoning

• Neuromuscular junction = myasthenia gravis, Lambert-Eating, organophosphates, botulism

• Muscle fibers = muscular dystorphy, polymyositis, dermatomyositis, hypothyroidism, corticosteroids, HIV