Antiemetics

Antihistamines

  • Dimenhydrinate

    • Indications: Motion sickness, postoperative nausea/vomiting

    • Dose: 50 mg PO every 4 to 6 hours (MDD 400 mg/day)

    • Pregnancy category B

  • Meclizine

    • Indications: Motion sickness, vertigo

    • Dose: 25 mg PO every 6 hours (MDD 100 mg/day)

    • Pregnancy category: Unknown

Antimuscarinic: Scopolamine

  • Indications: Motion sickness, postoperative nausea/vomiting

  • Contraindications: Glaucoma, megacolon, obstructive prostatic hypertrophy, myasthenia gravis

  • Dosing

    • Apply 1 patch behind ear daily

    • 10 mg PO every 8 hours (MDD 60 mg/day)

  • Pregnancy category: Avoid transdermal patch use in women with preeclampsia

5HT3 Antagonist: Ondansetron

  • Indications

    • Generalized N/V

    • N/V due to gastroparesis, pregnancy, vertigo, surgery, chemotherapy, radiation

D2 antagonists

  • Metoclopramide

  • Prochlorperazine

  • Promethazine